The SMDC maintains a suite of modern robotic instrumentation that permits high-throughput biochemical and cell-based screening of our compound collection.
HTS INSTRUMENTATION
Our HTS instrumentation is compatible with 96 or 384-well formats and includes liquid handlers, bulk dispensers, and plate readers. We have two instrument set-ups. Through a partnership with GE Healthcare Bio-sciences we have acquired the capability to perform high-throughput high-content cellular screening with the IN Cell Analyzer 2000, an automated epifluorescence based microscope system capable of imaging a 96-well plate in less than three minutes. This system is integrated with a Biomek FXp liquid handler, Biotek EL406 plate washer/dispense and Perkin Elmer Envision plate reader.
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Beckman FXp Liquid Handler |
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GE IN Cell Analyzer 2000 |
In addition, a smaller integrated system contains an GE Healthcare IN Cell Analyzer 1000 imaging system and a Molecular Devices Flexstation III plate reader
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Molecular Devices Flexstation III Plate Reader |
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GE IN Cell Analyzer 1000 |
Additional free-standing instrumentation with walk-up functionality includes a Molecular Devices Analyst HT, a Matrix Wellmate Bulk Dispense, a Biotek EL406 plate washer/dispenser and a Biacore 4000 high-through surface plasmon resonance (SPR) instrument
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Matrix WellMate Bulk Dispenser |
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Biotek EL406 Plate Washer/Dispenser |
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Molecular Devices Analyst HT Plate Reader |
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Biacore 4000 Surface Plasmon Resonance |
Chemistry Core INSTRUMENTATION
The Chemistry Core of the SMDC is supported by automated chromatographic purification capabilities. Our instrumentation includes the Biotage SP1 system for flash chromatography, a four-channel parallel HPLC with automated sample loading and fraction collection, and the Genevac Mega 1200 Series II high capacity evaporator. |
Biotage SP1 High-Performance Flash Chromatography (HPFC) System |
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Biotage ParallexFlex Four-Channel HPLC System |
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Genevac Mega 1200 Series II Evaporator |
