SMDC
Small Molecule Discovery Center
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About

The SMDC maintains a suite of modern robotic instrumentation that permits high-throughput biochemical and cell-based screening of our compound collection.

HTS INSTRUMENTATION

Our HTS instrumentation is compatible with 96 or 384-well formats and includes liquid handlers, bulk dispensers, and plate readers. Through a partnership with GE Healthcare Bio-sciences we have acquired the capability to perform medium-throughput high-content cellular screening with the IN Cell Analyzer 1000, an automated epifluorescence based microscope system capable of imaging a 96-well plate in less than three minutes.

Beckman FXp Liquid Handler
Matrix WellMate Bulk Dispenser
Molecular Devices Analyst AD Plate Reader
GE IN Cell Analyzer 1000
Matrix Platemate
  Velocity 11 Plate Loc Heat Sealer  

Chemistry Core INSTRUMENTATION

The Chemistry Core of the SMDC is supported by automated chromatographic purification capabilities. Our instrumentation includes the Biotage SP1 system for flash chromatography, a four-channel parallel HPLC with automated sample loading and fraction collection, and the Genevac Mega 1200 Series II high capacity evaporator.

Biotage SP1 High-Performance Flash Chromatography (HPFC) System
Biotage ParallexFlex Four-Channel HPLC System
Genevac Mega 1200 Series II Evaporator

INSTRUMENTATION

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