The SMDC maintains a suite of modern robotic instrumentation that permits high-throughput biochemical and cell-based screening of our compound collection.
Our HTS instrumentation is compatible with 96 or 384-well formats and includes liquid handlers, bulk dispensers, and plate readers. We have two instrument set-ups. Through a partnership with GE Healthcare Bio-sciences we have acquired the capability to perform high-throughput high-content cellular screening with the IN Cell Analyzer 2000, an automated epifluorescence based microscope system capable of imaging a 96-well plate in less than three minutes. This system is integrated with a Biomek FXp liquid handler, Biotek EL406 plate washer/dispense and Perkin Elmer Envision plate reader.
|Beckman FXp Liquid Handler|
|GE IN Cell Analyzer 2000|
In addition, a smaller integrated system contains an GE Healthcare IN Cell Analyzer 1000 imaging system and a Molecular Devices Flexstation III plate reader
|Molecular Devices Flexstation III Plate Reader|
|GE IN Cell Analyzer 1000|
Additional free-standing instrumentation with walk-up functionality includes a Molecular Devices Analyst HT, a Matrix Wellmate Bulk Dispense, a Biotek EL406 plate washer/dispenser and a Biacore 4000 high-through surface plasmon resonance (SPR) instrument
|Matrix WellMate Bulk Dispenser|
|Biotek EL406 Plate Washer/Dispenser|
|Molecular Devices Analyst HT Plate Reader|
|Biacore 4000 Surface Plasmon Resonance|
|Biotage SP1 High-Performance Flash Chromatography (HPFC) System|
|Biotage ParallexFlex Four-Channel HPLC System|
|Genevac Mega 1200 Series II Evaporator|